SD 2590 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 3269
• Prices: $205.00, $845.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 226395-93-3
• Chemical Name: N-Hydroxy-1-(2-methoxyethyl)-4-[4-[4-(trifluoromethoxy)phenoxy]phenyl]sulfonyl]-4-piperidinecarboxamidehydrochloride
• Formula: C22H25F3N2O7S.HCl
• Molecular Weight: 554.96
• Purity: >98 %
• Description: Potent MMP inhibitor (IC 50 values are <0.1, <0.1, 0.18, 1.7, 13 and 28.7 nM for MMP-2, -13, -9, -8, -14 and -3 respectively). Exhibits 100,000-fold selectivity for MMP-2 and -13 over MMP-1. Reduces left ventricular dilation in a myocardial infarction rat model. Orally bioavailable.

Product References

Orally active MMP-1 sparing alpha-tetrahydropyranyl and alpha-piperidinyl sulfone - Orally active MMP-1 sparing alpha-tetrahydropyranyl and alpha-piperidinyl sulfone

Becker DP, Barta TE, Bedell LJ, Boehm TL, Bond BR, Carroll J, Carron CP, Decrescenzo GA, Easton AM, Freskos JN, Funckes-Shippy CL, Heron M, Hockerman S, Howard CP, Kiefer JR, Li MH, Mathis KJ, McDonald JJ, Mehta PP, Munie GE, Sunyer T, Swearingen CA, Villamil CI, Welsch D, Williams JM, Yu Y, Yao J. J Med Chem. 2010 Sep 23;53(18):6653-80.