SDZ NKT 343

• Supplier: Tocris Bioscience
• Catalog: 1250
• Prices: $279.00
• Sizes: 10 mg
• Function Type: Antagonist
• Cas Number: 180046-99-5
• Chemical Name: 1-[[(2-Nitrophenyl)amino]carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide
• Formula: C33H33N5O5
• Molecular Weight: 579.65
• Purity: >98 %
• Description: Highly selective human tachykinin NK 1 receptor antagonist (IC 50 values are 0.62 and 451 nM for human and rat receptors respectively) that displays > 130-fold selectivity over human NK 2 and NK 3 receptors. Potently antagonizes SP-induced Ca 2+ efflux in vitro and inhibits mechanical hyperalgesia in vivo .

Product References

Selective neurokinin-1 receptor antagonists are anti-hyperalgesic in a model of - Selective neurokinin-1 receptor antagonists are anti-hyperalgesic in a model of

Campbell EA, Gentry CT, Patel S, Panesar MS, Walpole CS, Urban L. Neuroscience. 1998 Dec;87(3):527-32.

Comparative, general pharmacology of SDZ NKT 343, a novel, selective NK1 receptor - Comparative, general pharmacology of SDZ NKT 343, a novel, selective NK1 receptor

Walpole CS, Brown MC, James IF, Campbell EA, McIntyre P, Docherty R, Ko S, Hedley L, Ewan S, Buchheit KH, Urban LA. Br J Pharmacol. 1998 May;124(1):83-92.

2-Nitrophenylcarbamoyl-(S)-prolyl-(S)-3-(2-naphthyl)alanyl-N-benzyl-N - - 2-Nitrophenylcarbamoyl-(S)-prolyl-(S)-3-(2-naphthyl)alanyl-N-benzyl-N -

Walpole C, Ko SY, Brown M, Beattie D, Campbell E, Dickenson F, Ewan S, Hughes GA, Lemaire M, Lerpiniere J, Patel S, Urban L. J Med Chem. 1998 Aug 13;41(17):3159-73.