SDZ SER 082 fumarate

Name SDZ SER 082 fumarate
Supplier Tocris Bioscience
Catalog 2394
Prices $189.00, $765.00
Sizes 10 mg, 50 mg
Function Type Antagonist
Cas Number 1417343-80-6
Chemical Name (+)-cis-4,5,7a,8,9,10,11,11a-Octahydro-7H-10-methylindolo[1,7-bc][2,6]-naphthyridinefumarate
Formula C15H20N2.C4H4O4
Molecular Weight 344.41
Description Selective 5-HT 2B/2C receptor antagonist with low affinity for 5-HT 1A receptors. Inhibits [ 3 H]-mesulergine binding to 5-HT 2C receptors with a pK D of 7.8. Inhibits 5-HT 2B mediated responses in the rat fundus (pK B = 7.34).
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Product References

(+)-cis-4,5,7a,8,9,10,11,11a-octahydro-7H-10-methylindolo[1,7- - (+)-cis-4,5,7a,8,9,10,11,11a-octahydro-7H-10-methylindolo[1,7-

Nozulak J, Kalkman HO, Floersheim P, Hoyer D, Schoeffter P, Buerki HR. J Med Chem. 1995 Jan 6;38(1):28-33.

Role of 5-HT2A and 5-HT2C receptor subtypes in the two types of fear generated by - Role of 5-HT2A and 5-HT2C receptor subtypes in the two types of fear generated by

Mora PO, Netto CF, Graeff FG. Pharmacol Biochem Behav. 1997 Dec;58(4):1051-7.

Cataleptogenic effect of subtype selective 5-HT receptor antagonists in the rat. - Cataleptogenic effect of subtype selective 5-HT receptor antagonists in the rat.

Kalkman HO, Neumann V, Nozulak J, Tricklebank MD. Eur J Pharmacol. 1998 Feb 19;343(2-3):201-7.