| Name | Selexipag |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 1836 |
| Prices | $225.00, $925.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Agonist |
| Cas Number | 475086-01-2 |
| Chemical Name | 2-[4-[(5,6-Diphenyl-2-pyrazinyl)(1-methylethyl)amino]butoxy]-N-(methylsulfonyl)acetamide |
| Formula | C26H32N4O4S |
| Molecular Weight | 496.62 |
| Purity | >98 % |
| Description | Selective prostacyclin IP 1 receptor agonist (K i values are 260 and 2100 nM and for human and rat IP receptors, and >10 μ M for EP 1-4 , DP, FP, and TP receptors). Prodrug for the active form of MRE 26. Ameliorates vascular endothelial dysfunction and increases femoral skin blood flow in rats. Orally available. |
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Roncarati R, Scali C, Comery TA, Grauer SM, Aschmi S, Bothmann H, Jow B, Kowal D, Gianfriddo M, Kelley C, Zanelli U, Ghiron C, Haydar S, Dunlop J, Terstappen GC. J Pharmacol Exp Ther. 2009 May;329(2):459-68.
Beinat C, Banister SD, van Prehn S, Doddareddy MR, Hibbs D, Sako M, Chebib M, Tran T, Al-Muhtasib N, Xiao Y, Kassiou M. Bioorg Med Chem Lett. 2012 Apr 1;22(7):2380-4.