| Name | Sephin 1 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 1068 |
| Prices | $129.00, $535.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Chemical Name | (2E)-2-[(2-Chlorophenyl)methylene]-hydrazinecarboximidamidecarbonicacidsalt |
| Formula | C8H9ClN4.CH2O3 |
| Molecular Weight | 258.66 |
| Purity | >98 % |
| Description | Inhibitor of the regulatory subunit PPP1R15A of protein phosphatase 1. Does not bind PPP1R15B or have α 2 adrenergic agonist activity. Cytoprotective in endoplasmic reticulum stressed cells in vitro . Prevents defects associated with protein misfolding in a mouse Charcot-Marie Tooth-1B model. Orally available. |
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Pasquini S, Botta L, Semeraro T, Mugnaini C, Ligresti A, Palazzo E, Maione S, Di Marzo V, Corelli F. J Med Chem. 2008 Aug 28;51(16):5075-84.
Contartese A, Valoti M, Corelli F, Pasquini S, Mugnaini C, Pessina F, Aldinucci C, Sgaragli G, Frosini M. Pharmacol Res. 2012 Dec;66(6):555-63.