SEW 2871

• Supplier: Tocris Bioscience
• Catalog: 2395
• Prices: $79.00, $335.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 256414-75-2
• Chemical Name: 5-[4-Phenyl-5-(trifluoromethyl)thiophen-2-yl]-3-[3-(trifluoromethyl)phenyl]1,2,4-oxadiazole
• Formula: C20H10F6N2OS
• Molecular Weight: 440.36
• Purity: >99 %
• Description: Novel, potent and selective sphingosine-1-phosphate 1 (S1P 1 ) receptor agonist. Activates S1P 1 receptor with an EC 50 of 13 nM, but does not activate S1P 2 , S1P 3 , S1P 4 or S1P 5 receptors at concentrations up to 10 μ M. Cell-permeable and active in vivo .

Product References

A rational utilization of high-throughput screening affords selective, orally - A rational utilization of high-throughput screening affords selective, orally

Hale JJ, Lynch CL, Neway W, Mills SG, Hajdu R, Keohane CA, Rosenbach MJ, Milligan JA, Shei GJ, Parent SA, Chrebet G, Bergstrom J, Card D, Ferrer M, Hodder P, Strulovici B, Rosen H, Mandala S. J Med Chem. 2004 Dec 30;47(27):6662-5.

Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, - Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively,

Sanna MG, Liao J, Jo E, Alfonso C, Ahn MY, Peterson MS, Webb B, Lefebvre S, Chun J, Gray N, Rosen H. J Biol Chem. 2004 Apr 2;279(14):13839-48. Epub 2004 Jan 19.

Sphingosine-1-phosphate prevents tumor necrosis factor-{alpha}-mediated monocyte - Sphingosine-1-phosphate prevents tumor necrosis factor-{alpha}-mediated monocyte

Bolick DT, Srinivasan S, Kim KW, Hatley ME, Clemens JJ, Whetzel A, Ferger N, Macdonald TL, Davis MD, Tsao PS, Lynch KR, Hedrick CC. Arterioscler Thromb Vasc Biol. 2005 May;25(5):976-81. Epub 2005 Mar 10.