| Name | SGC 0946 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5020 |
| Prices | $265.00, $1,085.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Chemical Name | 1-[3-[[[(2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl](isopropyl)amino]propyl]-3-[4-(2,2-dimethylethyl)phenyl]urea |
| Formula | C28H40BrN7O4 |
| Molecular Weight | 618.57 |
| Purity | >99 % |
| Description | Highly potent DOT1L methyltransferase inhibitor (K d = 0.06 nM, IC 50 = 0.3 nM in a radioactive assay); blocks H3K79 methylation in A431 cells and MCF10A cells. Inactive at 12 histone methyltransferases and DNMT1. Selectively kills cells transformed with the MLL-AF9 fusion oncogene in an in vitro model of leukemia; lowers levels of MLL target genes HOXA9 and Meis1 . |
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