| Name | SGC-CBP30 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5367 |
| Prices | $255.00, $1,045.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Chemical Name | 2-[2-(3-Chloro-4-methoxyphenyl)ethyl]-5-(dimethyl-1,2-oxazol-4-yl)-1-[(2S)-2-(morpholin-4-yl)propyl]-1H-1,3-benzodiazole |
| Formula | C28H33ClN4O3 |
| Molecular Weight | 509.04 |
| Purity | >98 % |
| Description | Potent CBP/p300 bromodomain (BRD) inhibitor (K d values are 21 and 32 nM for CBP and p300 BRDs respectively). Exhibits 40-fold and 250-fold selectivity for CBP over the first BRD of BRD4 (BRD4(1)) and BRD4(2) respectively. Accelerates FRAP recovery in cells at a concentration of 1 μ M. |
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Gallenkamp D, Gelato KA, Haendler B, Weinmann H. ChemMedChem. 2014 Mar;9(3):438-64.
Hay DA, Fedorov O, Martin S, Singleton DC, Tallant C, Wells C, Picaud S, Philpott M, Monteiro OP, Rogers CM, Conway SJ, Rooney TP, Tumber A, Yapp C, Filippakopoulos P, Bunnage ME, Muller S, Knapp S, Schofield CJ, Brennan PE. J Am Chem Soc. 2014 Jul 2;136(26):9308-19.