| Name | SGI 1027 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4889 |
| Prices | $179.00, $745.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 1020149-73-8 |
| Chemical Name | N-[4-[(2-Amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide |
| Formula | C27H23N7O |
| Molecular Weight | 461.52 |
| Purity | >99 % |
| Description | DNA methyltransferase inhibitor. Inhibits the mammalian DNA methyltransferases DNMT3B, DNMT3A and DNMT1 (IC 50 values are 7.5, 8 and 12.5 μ M with Poly(dl-dC) as the substrate). Reactivates silenced tumor suppressor genes by reducing CpG island hypermethylation. |
| Supplier Page | Shop |
Datta J, Ghoshal K, Denny WA, Gamage SA, Brooke DG, Phiasivongsa P, Redkar S, Jacob ST. Cancer Res. 2009 May 15;69(10):4277-85.
Garcia-Dominguez P, Dell'aversana C, Alvarez R, Altucci L, de Lera AR. Bioorg Med Chem Lett. 2013 Mar 15;23(6):1631-5.