SGX 523

• Supplier: Tocris Bioscience
• Catalog: 3688
• Prices: $245.00, $1,005.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1022150-57-7
• Chemical Name: 6-[[6-(1-Methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]quinoline
• Formula: C18H13N7S
• Molecular Weight: 359.41
• Purity: >99 %
• Description: Potent and selective c-MET kinase inhibitor (IC 50 = 4nM). Exhibits minimal inhibition against a panel of 213 other protein kinases (at 1 μ M). Suppresses growth of tumor xenografts derived from human glioblastoma, lung and gastric cancer cells.

Product References

SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor - SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor

Buchanan SG, Hendle J, Lee PS, Smith CR, Bounaud PY, Jessen KA, Tang CM, Huser NH, Felce JD, Froning KJ, Peterman MC, Aubol BE, Gessert SF, Sauder JM, Schwinn KD, Russell M, Rooney IA, Adams J, Leon BC, Do TH, Blaney JM, Sprengeler PA, Thompson DA, Smyth L, Pelletier LA, Atwell S, Holme K, Wasserman SR, Emtage S, Burley SK, Reich SH. Mol Cancer Ther. 2009 Dec;8(12):3181-90.