SHA 68

• Supplier: Tocris Bioscience
• Catalog: 5356
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 847553-89-3
• Chemical Name: N-[(4-Fluorophenyl)methyl]tetrahydro-3-oxo-1,1-diphenyl-3H-oxazolo[3,4-a]pyrazine-7(1H)-carboxamide
• Formula: C26H24FN3O3
• Molecular Weight: 445.49
• Purity: >98 %
• Description: Selective neuropeptide S receptor (NPSR) antagonist (IC 50 values are 22.0 and 23.8 nM for human NPSR Asn107 and Ile107 variants respectively). Displays no activity against a range of 14 GPCRs, including vasopressin and oxytocin receptors.

Product References

Synthesis and pharmacological in vitro and in vivo profile of - Synthesis and pharmacological in vitro and in vivo profile of

Okamura N, Habay SA, Zeng J, Chamberlin AR, Reinscheid RK. J Pharmacol Exp Ther. 2008 Jun;325(3):893-901.

Neuropeptide S enhances memory during the consolidation phase and interacts with - Neuropeptide S enhances memory during the consolidation phase and interacts with

Okamura N, Garau C, Duangdao DM, Clark SD, Jungling K, Pape HC, Reinscheid RK. Neuropsychopharmacology. 2011 Mar;36(4):744-52.

Synthesis and separation of the enantiomers of the neuropeptide S receptor - Synthesis and separation of the enantiomers of the neuropeptide S receptor

Trapella C, Pela M, Del Zoppo L, Calo G, Camarda V, Ruzza C, Cavazzini A, Costa V, Bertolasi V, Reinscheid RK, Salvadori S, Guerrini R. J Med Chem. 2011 Apr 28;54(8):2738-44.