SHU 9119

• Supplier: Tocris Bioscience
• Catalog: 3220
• Prices: $129.00
• Sizes: 1 mg
• Function Type: Antagonist
• Cas Number: 168482-23-3
• Formula: C54H71N15O9
• Molecular Weight: 1074.25
• Description: Potent melanocortin MC 3 and MC 4 receptor antagonist (IC 50 values are 0.23 and 0.06 nM respectively) and MC 5 partial agonist (EC 50 = 0.12 nM). Upregulates expression of genes promoting lipogenesis and triglyceride storage (SCD1, LPL, ACC α and FAS), increases triglyceride synthesis and promotes insulin resistance. Increases food intake, body weight and fat mass when administered centrally in vivo .

Product References

Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5, D-Phe7,Lys10] - Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5, D-Phe7,Lys10]

Hruby VJ, Lu D, Sharma SD, Castrucci AL, Kesterson RA, al-Obeidi FA, Hadley ME, Cone RD. J Med Chem. 1995 Sep 1;38(18):3454-61.

Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: - Further structure-activity studies of lactam derivatives of MT-II and SHU-9119:

Grieco P, Cai M, Han G, Trivedi D, Campiglia P, Novellino E, Hruby VJ. Peptides. 2007 Jun;28(6):1191-6. Epub 2007 Mar 1.

The central melanocortin system directly controls peripheral lipid metabolism. - The central melanocortin system directly controls peripheral lipid metabolism.

Nogueiras R, Wiedmer P, Perez-Tilve D, Veyrat-Durebex C, Keogh JM, Sutton GM, Pfluger PT, Castaneda TR, Neschen S, Hofmann SM, Howles PN, Morgan DA, Benoit SC, Szanto I, Schrott B, Schurmann A, Joost HG, Hammond C, Hui DY, Woods SC, Rahmouni K, Butler AA, Farooqi IS, O'Rahilly S, Rohner-Jeanrenaud F, Tschop MH. J Clin Invest. 2007 Nov;117(11):3475-88.