SI-2 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 4923
• Prices: $165.00, $695.00
• Sizes: 10 mg, 50 mg
• Function Type: Activator
• Chemical Name: 1-(2-Pyridinyl)ethanone2-(1-methyl-1H-benzimidazol-2-yl)hydrazonehydrochloride
• Formula: C15H15N5.HCl
• Molecular Weight: 301.78
• Purity: >98 %
• Description: Potent steroid receptor coactivator 3 (SRC-3) inhibitor. Reduces SRC1, SRC2 and SRC3 levels in breast cancer cell lines. Inhibits cell growth (IC 50 = 3.4 nM), induces apoptosis and attenuates migration of MDA-MB48 breast cancer cells in vitro . Inhibits tumor growth in a MDA-MB48 cell breast cancer mouse model. Orally available.

Product References

(S)-(-)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine maleate (SIB-1508Y): a - (S)-(-)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine maleate (SIB-1508Y): a

Cosford ND, Bleicher L, Herbaut A, McCallum JS, Vernier JM, Dawson H, Whitten JP, Adams P, Chavez-Noriega L, Correa LD, Crona JH, Mahaffy LS, Menzaghi F, Rao TS, Reid R, Sacaan AI, Santori E, Stauderman KA, Whelan K, Lloyd GK, McDonald IA. J Med Chem. 1996 Aug 16;39(17):3235-7.

Nicotinic acetylcholine receptor agonist SIB-1508Y improves cognitive functioning - Nicotinic acetylcholine receptor agonist SIB-1508Y improves cognitive functioning

Schneider JS, Tinker JP, Van Velson M, Menzaghi F, Lloyd GK. J Pharmacol Exp Ther. 1999 Aug;290(2):731-9.