SIB 1893

• Supplier: Tocris Bioscience
• Catalog: 1215
• Prices: $129.00, $535.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 6266-99-5
• Chemical Name: 2-Methyl-6-(2-phenylethenyl)pyridine
• Formula: C14H13N
• Molecular Weight: 195.26
• Description: A highly selective non-competitive antagonist for the metabotropic glutamate mGlu 5 receptor subtype; displays an IC 50 value of 0.3 μ M at hmGlu 5 , compared with > 100 μ M at hmGlu 1b , hmGlu 2 , hmGlu 6 , hmGlu 7 and hmGlu 8 . Centrally active upon systemic administration in vivo . Positive allosteric modulator at mGlu 4 receptors.

Product References

SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic - SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic

Varney MA, Cosford ND, Jachec C, Rao SP, Sacaan A, Lin FF, Bleicher L, Santori EM, Flor PJ, Allgeier H, Gasparini F, Kuhn R, Hess SD, Velicelebi G, Johnson EC. J Pharmacol Exp Ther. 1999 Jul;290(1):170-81.

Anticonvulsant activity of two metabotropic glutamate group I antagonists - Anticonvulsant activity of two metabotropic glutamate group I antagonists

Chapman AG, Nanan K, Williams M, Meldrum BS. Neuropharmacology. 2000 Jul 10;39(9):1567-74.

Positive allosteric modulation of the human metabotropic glutamate receptor 4 - Positive allosteric modulation of the human metabotropic glutamate receptor 4

Mathiesen JM, Svendsen N, Brauner-Osborne H, Thomsen C, Ramirez MT. Br J Pharmacol. 2003 Mar;138(6):1026-30.