SID 26681509

• Supplier: Tocris Bioscience
• Catalog: 2290
• Prices: $209.00, $879.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 958772-66-2
• Chemical Name: N-[(1,1-Dimethylethoxy)carbonyl]-L-tryptophan-2-[[[2-[(2-ethylphenyl)amino]-2-oxoethyl]thio]carbonyl]hydrazide
• Formula: C27H33N5O5S
• Molecular Weight: 539.65
• Purity: >97 %
• Description: Potent and reversible human cathepsin L inhibitor (IC 50 = 56 nM). Displays no inhibitory activity at cathepsin G. Antimalarial; inhibits leishmaniasis.

Product References

Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor. - Identification and synthesis of a unique thiocarbazate cathepsin L inhibitor.

Myers MC, Shah PP, Diamond SL, Huryn DM, Smith AB 3rd. Bioorg Med Chem Lett. 2008 Jan 1;18(1):210-4. Epub 2007 Nov 1.

Kinetic characterization and molecular docking of a novel, potent, and selective - Kinetic characterization and molecular docking of a novel, potent, and selective

Shah PP, Myers MC, Beavers MP, Purvis JE, Jing H, Grieser HJ, Sharlow ER, Napper AD, Huryn DM, Cooperman BS, Smith AB 3rd, Diamond SL. Mol Pharmacol. 2008 Jul;74(1):34-41.