SID 7969543

• Supplier: Tocris Bioscience
• Catalog: 3625
• Prices: $129.00, $535.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 868224-64-0
• Chemical Name: Ethyl2-[[2-[2-[(2,3-Dihydro-1,4-benzodioxin-6-yl)amino]-2-oxoethyl]-1,2-dihydro-1-oxo-5-isoquinolinyl]oxy]propanoate
• Formula: C24H24N2O7
• Molecular Weight: 452.46
• Purity: >98 %
• Description: Selective steroidogenic factor-1 (SF-1, NR5A1) inhibitor (IC 50 values are 0.76, >33 and >33 μ M at SF-1, ROR α and VP16 respectively). Inhibits SF-1-dependent luciferase expression in HEK 293T cells in vitro (IC 50 = 30 nM).

Product References

Potent, selective and cell penetrant inhibitors of SF-1 by functional - Potent, selective and cell penetrant inhibitors of SF-1 by functional

Madoux F, Li X, Chase P, Zastrow G, Cameron MD, Conkright JJ, Griffin PR, Thacher S, Hodder P. Mol Pharmacol. 2008 Jun;73(6):1776-84.

Synthesis of small molecule inhibitors of the orphan nuclear receptor - Synthesis of small molecule inhibitors of the orphan nuclear receptor

Roth J, Madoux F, Hodder P, Roush WR. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2628-32.