Sildenafil citrate

• Supplier: Tocris Bioscience
• Catalog: 1148
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 171599-83-0
• Chemical Name: 1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazinecitrate
• Formula: C22H30N6O4S.C6H8O7
• Molecular Weight: 666.7
• Purity: >99 %
• Description: Orally active, potent inhibitor of phosphodiesterase 5 (PDE5) (IC 50 = 4 nM). Enhances nitric oxide-dependent relaxation of human corpus cavernosum in vitro .

Product References

Effects of sildenafil on the relaxation of human corpus cavernosum tissue in - Effects of sildenafil on the relaxation of human corpus cavernosum tissue in

Ballard SA, Gingell CJ, Tang K, Turner LA, Price ME, Naylor AM. J Urol. 1998 Jun;159(6):2164-71.

Inhibition of cyclic GMP-binding cyclic GMP-specific phosphodiesterase (Type 5) - Inhibition of cyclic GMP-binding cyclic GMP-specific phosphodiesterase (Type 5)

Turko IV, Ballard SA, Francis SH, Corbin JD. Mol Pharmacol. 1999 Jul;56(1):124-30.

Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and - Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and

Ghofrani HA, Osterloh IH, Grimminger F. Nat Rev Drug Discov. 2006 Aug;5(8):689-702.