Simvastatin

• Supplier: Tocris Bioscience
• Catalog: 3784
• Prices: $175.00
• Sizes: 50 mg
• Function Type: Inhibitor
• Cas Number: 79902-63-9
• Chemical Name: (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyly-2,2-dimethylbutanoate
• Formula: C25H38O5
• Molecular Weight: 418.57
• Purity: >98 %
• Description: HMG-CoA reductase inhibitor; decreases levels of low density lipoprotein. Has multiple biological effects including bone formation stimulation, inhibition of smooth muscle cell proliferation and migration, and anticancer and anti-inflammatory activity. Inactive lactone prodrug of simvastatin hydroxy acid, naturally bioactivated in vivo following oral administration.

Product References

Pharmacological effects of HMG CoA reductase inhibitors other than lipoprotein - Pharmacological effects of HMG CoA reductase inhibitors other than lipoprotein

White CM. J Clin Pharmacol. 1999 Feb;39(2):111-8.

Statins and bone formation. - Statins and bone formation.

Garrett IR, Gutierrez G, Mundy GR. Curr Pharm Des. 2001 May;7(8):715-36.

Preclinical pharmacokinetics of statins. - Preclinical pharmacokinetics of statins.

Reinoso RF, Sanchez Navarro A, Garcia MJ, Prous JR. Methods Find Exp Clin Pharmacol. 2002 Nov;24(9):593-613.

Potential anticancer effects of statins: fact or fiction? - Potential anticancer effects of statins: fact or fiction?

Kaushal V, Kohli M, Mehta P, Mehta JL. Endothelium. 2003;10(1):49-58.