SIN-1 chloride

• Supplier: Tocris Bioscience
• Catalog: 5536
• Prices: $139.00
• Sizes: 50 mg
• Function Type: Inhibitor
• Cas Number: 16142-27-1
• Chemical Name: Amino-3-morpholinyl-1,2,3-oxadiazoliumchloride
• Formula: C6H11ClN4O2
• Molecular Weight: 206.63
• Purity: >98 %
• Description: This compound (the active product of the prodrug SIN-10, molsidomine) acts as a vasodilator and inhibitor of platelet aggregation; longer acting than nitroprusside or nitroglycerin. Decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion.

Product References

Inhibition of platelet aggregation and stimulation of guanylate cyclase by an - Inhibition of platelet aggregation and stimulation of guanylate cyclase by an

Nishikawa M, Kanamori M, Hidaka H. J Pharmacol Exp Ther. 1982 Jan;220(1):183-90.

Molecular basis of the synergistic inhibition of platelet function by - Molecular basis of the synergistic inhibition of platelet function by

Maurice DH, Haslam RJ. Mol Pharmacol. 1990 May;37(5):671-81.

Cardioprotection and attenuation of endothelial dysfunction by organic nitric - Cardioprotection and attenuation of endothelial dysfunction by organic nitric

Siegfried MR, Erhardt J, Rider T, Ma XL, Lefer AM. J Pharmacol Exp Ther. 1992 Feb;260(2):668-75.