Sipatrigine

• Supplier: Tocris Bioscience
• Catalog: 3848
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Blocker
• Cas Number: 130800-90-7
• Chemical Name: 2-(4-Methyl-1-piperazinyl)-5-(2,3,5-trichlorophenyl)-4-pyrimidinamine
• Formula: C15H16Cl3N5
• Molecular Weight: 372.68
• Purity: >99 %
• Description: Blocker of voltage-dependent sodium channels (Na V ). Inhibits glutamate release; displays neuroprotective activity in rat models of cerebral ischemia. Also thought to block Ca 2+ channels. Analog of lamotrigine (Cat. No. 1611).

Product References

BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic - BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic

Leach MJ, Swan JH, Eisenthal D, Dopson M, Nobbs M. Stroke. 1993 Jul;24(7):1063-7.

Neuroprotective effects of a use-dependent blocker of voltage-dependent sodium - Neuroprotective effects of a use-dependent blocker of voltage-dependent sodium

Graham SH, Chen J, Lan J, Leach MJ, Simon RP. J Pharmacol Exp Ther. 1994 May;269(2):854-9.

On the inhibition of voltage activated calcium currents in rat cortical neurones - On the inhibition of voltage activated calcium currents in rat cortical neurones

Stefani A, Hainsworth AH, Spadoni F, Bernardi G. Br J Pharmacol. 1998 Nov;125(5):1058-64.