SirReal 2

• Supplier: Tocris Bioscience
• Catalog: 4044
• Prices: $195.00, $805.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 709002-46-0
• Chemical Name: 2-[(4,6-Dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]acetamide
• Formula: C22H20N4OS2
• Molecular Weight: 420.55
• Purity: >98 %
• Description: Selective SIRT2 inhibitor (IC 50 = 140 nM). Has minimal effect on SIRT1 and SIRT3-6. Increases α -tubulin acetylation levels in HeLa cells.

Product References

Selective Sirt2 inhibition by ligand-induced rearrangement of the active site. - Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.

Rumpf T, Schiedel M, Karaman B, Roessler C, North BJ, Lehotzky A, Olah J, Ladwein KI, Schmidtkunz K, Gajer M, Pannek M, Steegborn C, Sinclair DA, Gerhardt S, Ovadi J, Schutkowski M, Sippl W, Einsle O, Jung M. Nat Commun. 2015 Feb 12;6:6263.