Sirtinol

• Supplier: Tocris Bioscience
• Catalog: 5457
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 410536-97-9
• Chemical Name: 2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)benzamide
• Formula: C26H22N2O2
• Molecular Weight: 394.47
• Purity: >98 %
• Description: Cell-permeable, selective sirtuin deacetylase inhibitor (IC 50 values are 38, 68 and 131 μ M at SIRT2, Sir2p and SIRT1 respectively) that has no effect on HDAC1 activity. Significantly decreases growth and viability of PCa and HEK293T cells in vitro .

Product References

Identification of a class of small molecule inhibitors of the sirtuin family of - Identification of a class of small molecule inhibitors of the sirtuin family of

Grozinger CM, Chao ED, Blackwell HE, Moazed D, Schreiber SL. J Biol Chem. 2001 Oct 19;276(42):38837-43. Epub 2001 Aug 1.

Design, synthesis, and biological evaluation of sirtinol analogues as class III - Design, synthesis, and biological evaluation of sirtinol analogues as class III

Mai A, Massa S, Lavu S, Pezzi R, Simeoni S, Ragno R, Mariotti FR, Chiani F, Camilloni G, Sinclair DA. J Med Chem. 2005 Dec 1;48(24):7789-95.

A novel chalcone polyphenol inhibits the deacetylase activity of SIRT1 and cell - A novel chalcone polyphenol inhibits the deacetylase activity of SIRT1 and cell

Kahyo T, Ichikawa S, Hatanaka T, Yamada MK, Setou M. J Pharmacol Sci. 2008 Nov;108(3):364-71. Epub 2008 Nov 13.

Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for - Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for

Jung-Hynes B, Nihal M, Zhong W, Ahmad N. J Biol Chem. 2009 Feb 6;284(6):3823-32.