SIS3

• Supplier: Tocris Bioscience
• Catalog: 3521
• Prices: $235.00, $965.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 521984-48-5
• Chemical Name: 1,2,3,4-Tetrahydro-6,7-dimethoxy-2-[(2E)-3-(1-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-oxo-2-propenyl]-isoquinolinehydrochloride
• Formula: C28H27N3O3.HCl
• Molecular Weight: 489.99
• Purity: >98 %
• Description: Selective Smad3 inhibitor; attenuates TGF- β 1-dependent Smad3 phosphorylation and DNA binding. Has no effect on Smad2, p38 MAPK, ERK or PI 3-kinase signaling. Inhibits TGF- β 1-induced myofibroblast differentiation of dermal fibroblasts. Also inhibits TGF- β 2-induced endothelial cell differentiation in iPSCs.

Product References

Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on - Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on

Jinnin M, Ihn H, Tamaki K. Mol Pharmacol. 2006 Feb;69(2):597-607. Epub 2005 Nov 15.

Wild-type and mutant p53 differentially regulate NADPH oxidase 4 in - Wild-type and mutant p53 differentially regulate NADPH oxidase 4 in

Boudreau HE, Casterline BW, Burke DJ, Leto TL. Br J Cancer. 2014 May 13;110(10):2569-82.

Endothelial lineage differentiation from induced pluripotent stem cells is - Endothelial lineage differentiation from induced pluripotent stem cells is

Di Bernardini E, Campagnolo P, Margariti A, Zampetaki A, Karamariti E, Hu Y, Xu Q. J Biol Chem. 2014 Feb 7;289(6):3383-93.