SKA 31

• Supplier: Tocris Bioscience
• Catalog: 1079
• Prices: $109.00, $455.00
• Sizes: 10 mg, 50 mg
• Function Type: Activator
• Cas Number: 40172-65-4
• Chemical Name: Naphtho[1,2-d]thiazol-2-ylamine
• Formula: C11H8N2S
• Molecular Weight: 200.26
• Purity: >99 %
• Description: Activator of K Ca 3.1 and K Ca 2 channels (EC 50 values are 260, 2900, 2900 nM for K Ca 3.1, K Ca 2.1 and K Ca 2.2 respectively). Potentiates acetylcholine-induced EDHF-type dilations of mouse carotid arteries and lowers blood pressure in normotensive and hypertensive mice.

Product References

Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived - Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived

Brahler S, Kaistha A, Schmidt VJ, Wolfle SE, Busch C, Kaistha BP, Kacik M, Hasenau AL, Grgic I, Si H, Bond CT, Adelman JP, Wulff H, de Wit C, Hoyer J, Kohler R. Circulation. 2009 May 5;119(17):2323-32.

Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 - Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1

Sankaranarayanan A, Raman G, Busch C, Schultz T, Zimin PI, Hoyer J, Kohler R, Wulff H. Mol Pharmacol. 2009 Feb;75(2):281-95.