| Name | SKF 86002 dihydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 2074 |
| Prices | $189.00, $765.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 116339-68-5 |
| Chemical Name | 6-(4-Fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo[2,1-b]thiazoledihydrochloride |
| Formula | C16H12FN3S.2HCl |
| Molecular Weight | 370.27 |
| Purity | >98 % |
| Description | Inhibitor of p38 MAP kinase (IC 50 = 0.1 - 1 μ M). Potently inhibits LPS-induced IL-1 and TNF- α production in human monocytes (IC 50 = 1 μ M). Also inhibits 5-lipoxygenase- and cyclooxygenase-mediated arachidonic acid metabolism in RBL-1 cells (IC 50 values are 10 and 100 μ M respectively). Anti-inflammatory following oral administration in vivo . |
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