SKF 89976A hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 3866
• Prices: $139.00, $579.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 85375-15-1
• Chemical Name: 1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylicacidhydrochloride
• Formula: C22H25NO2.HCl
• Molecular Weight: 371.91
• Purity: >99 %
• Description: A potent GABA uptake inhibitor, selective for GAT-1 (IC 50 values are 0.13, 550, 944 and 7210 μ M for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). Inhibits transport current competitively (K i = 7 μ M) and transmitter-gated current non-competitively (K i = 0.03 nM). Able to pass the blood-brain barrier after systemic administration and is active in vivo .

Product References

Orally active and potent inhibitors of gamma-aminobutyric acid uptake. - Orally active and potent inhibitors of gamma-aminobutyric acid uptake.

Ali FE, Bondinell WE, Dandridge PA, Frazee JS, Garvey E, Girard GR, Kaiser C, Ku TW, Lafferty JJ, Moonsammy GI, et al.. J Med Chem. 1985 May;28(5):653-60.

Identification and selective inhibition of the channel mode of the neuronal GABA - Identification and selective inhibition of the channel mode of the neuronal GABA

Krause S, Schwarz W. Mol Pharmacol. 2005 Dec;68(6):1728-35. Epub 2005 Sep 8.