SL 0101-1

Name SL 0101-1
Supplier Tocris Bioscience
Catalog 4817
Prices $299.00
Sizes 1 mg
Function Type Inhibitor
Cas Number 77307-50-7
Chemical Name 3-[(3,4-Di-O-acetyl-6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydro-2-(4-hydroxyphenyl)-4H-1benzopyran-4-one
Formula C25H24O12
Molecular Weight 516.46
Purity >95 %
Description Selective inhibitor of ribosomal S6 kinase (RSK) (IC 50 = 89 nM for RSK2). Does not inhibit upstream kinases such as MEK, Raf and PKC. Inhibits the growth of MCF-7 human breast cancer cells with no effect on the normal breast cell line.
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Product References

Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) - Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK)

Smith JA, Poteet-Smith CE, Xu Y, Errington TM, Hecht SM, Lannigan DA. Cancer Res. 2005 Feb 1;65(3):1027-34.

The selectivity of protein kinase inhibitors: a further update. - The selectivity of protein kinase inhibitors: a further update.

Bain J, Plater L, Elliott M, Shpiro N, Hastie CJ, McLauchlan H, Klevernic I, Arthur JS, Alessi DR, Cohen P. Biochem J. 2007 Dec 15;408(3):297-315.