SL 327

• Supplier: Tocris Bioscience
• Catalog: 2250
• Prices: $95.00, $205.00, $845.00
• Sizes: 1 mg, 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 305350-87-2
• Chemical Name: α-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile
• Formula: C16H12F3N3S
• Molecular Weight: 335.35
• Purity: >99 %
• Description: Selective inhibitor of MEK1 and MEK2 (IC 50 values are 0.18 and 0.22 μ M respectively); blocks hippocampal LTP in vitro . Brain penetrant in vivo , blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration.

Product References

The MAPK/ERK cascade targets both Elk-1 and cAMP response element-binding protein - The MAPK/ERK cascade targets both Elk-1 and cAMP response element-binding protein

Davis S, Vanhoutte P, Pages C, Caboche J, Laroche S. J Neurosci. 2000 Jun 15;20(12):4563-72.

Regulation of cyclooxygenase-2 induction in the mouse uterus during - Regulation of cyclooxygenase-2 induction in the mouse uterus during

Scherle PA, Ma W, Lim H, Dey SK, Trzaskos JM. J Biol Chem. 2000 Nov 24;275(47):37086-92.

Significant neuroprotection against ischemic brain injury by inhibition of the - Significant neuroprotection against ischemic brain injury by inhibition of the

Wang X, Wang H, Xu L, Rozanski DJ, Sugawara T, Chan PH, Trzaskos JM, Feuerstein GZ. J Pharmacol Exp Ther. 2003 Jan;304(1):172-8.