(±)-SLV 319

• Supplier: Tocris Bioscience
• Catalog: 1468
• Prices: $209.00, $879.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 362519-49-1
• Chemical Name: 3-(4-Chlorophenyl)-N-[(4-Chlorophenyl)sulfonyl]-4,5-dihydro-N'-methyl-4-phenyl-1H-pyrazole-1-carboximidamide
• Formula: C23H20Cl2N4O2S
• Molecular Weight: 487.4
• Purity: >98 %
• Description: Potent and selective CB 1 receptor antagonist (K i = 7.8 nM). Exhibits 1000-fold selectivity for CB 1 over CB 2 receptors. Inhibits CP 55,940 -induced hypotension and WIN 55,212-2 -induced hypothermia in vivo . Orally active.

Product References

Synthesis, biological properties, and molecular modeling investigations of novel - Synthesis, biological properties, and molecular modeling investigations of novel

Lange JH, Coolen HK, van Stuivenberg HH, Dijksman JA, Herremans AH, Ronken E, Keizer HG, Tipker K, McCreary AC, Veerman W, Wals HC, Stork B, Verveer PC, den Hartog AP, de Jong NM, Adolfs TJ, Hoogendoorn J, Kruse CG. J Med Chem. 2004 Jan 29;47(3):627-43.

Novel 3,4-diarylpyrazolines as potent cannabinoid CB1 receptor antagonists with - Novel 3,4-diarylpyrazolines as potent cannabinoid CB1 receptor antagonists with

Lange JH, van Stuivenberg HH, Veerman W, Wals HC, Stork B, Coolen HK, McCreary AC, Adolfs TJ, Kruse CG. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4794-8.