SM 324405

• Supplier: Tocris Bioscience
• Catalog: 3344
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 677773-91-0
• Chemical Name: Methyl3-[(6-amino-2-butoxy-7,8-dihydro-8-oxo-9H-purin-9-yl)methyl]benzeneacetate
• Formula: C19H23N5O4
• Molecular Weight: 385.42
• Purity: >98 %
• Description: Potent TLR7 agonist (EC 50 = 50 nM). Exhibits selectivity for TLR7 over TLR8. Induces IFN- α and - γ expression in human PBMCs and mouse splenocytes, and inhibits IL-5 production in human PBMCs in vitro . Rapidly metabolized to acid metabolite (t ½ = 2.6 min in human plasma).

Product References

Antinociceptive profile of 3-alpha-tropanyl 2-(4-Cl-phenoxy)butyrate (SM-21) - Antinociceptive profile of 3-alpha-tropanyl 2-(4-Cl-phenoxy)butyrate (SM-21)

Ghelardini C, Galeotti N, Gualtieri F, Bellucci C, Manetti D, Giotti A, Malmberg-Aiello P, Galli A, Bartolini A. J Pharmacol Exp Ther. 1997 Jul;282(1):430-9.

Pharmacological identification of SM-21, the novel sigma(2) antagonist. - Pharmacological identification of SM-21, the novel sigma(2) antagonist.

Ghelardini C, Galeotti N, Bartolini A. Pharmacol Biochem Behav. 2000 Nov;67(3):659-62.

(+/-)-SM 21 attenuates the convulsive and locomotor stimulatory effects of - (+/-)-SM 21 attenuates the convulsive and locomotor stimulatory effects of

Matsumoto RR, Mack AL. Eur J Pharmacol. 2001 Apr 6;417(1-2):R1-2.