SMER 28

• Supplier: Tocris Bioscience
• Catalog: 5314
• Prices: $109.00, $459.00
• Sizes: 10 mg, 50 mg
• Cas Number: 307538-42-7
• Chemical Name: 6-Bromo-N-2-propenyl-4-quinazolinamine
• Formula: C11H10BrN3
• Molecular Weight: 264.12
• Purity: >99 %
• Description: Positive regulator of autophagy in a mechanism independent from the mTOR pathway. Increases autophagosome synthesis and enhances clearance of model autophagy substrates such as mutant huntingtin and A53T α -synuclein, associated with Huntington's and Parkinson's diseases, respectively. Promotes reprogramming of fibroblasts to neural stem-like cells in combination with other chemical reagents.

Product References

Chemical inducers of autophagy that enhance the clearance of mutant proteins in - Chemical inducers of autophagy that enhance the clearance of mutant proteins in

Renna M, Jimenez-Sanchez M, Sarkar S, Rubinsztein DC. J Biol Chem. 2010 Apr 9;285(15):11061-7.

Small molecules enhance autophagy and reduce toxicity in Huntington's disease - Small molecules enhance autophagy and reduce toxicity in Huntington's disease

Sarkar S, Perlstein EO, Imarisio S, Pineau S, Cordenier A, Maglathlin RL, Webster JA, Lewis TA, O'Kane CJ, Schreiber SL, Rubinsztein DC. Nat Chem Biol. 2007 Jun;3(6):331-8. Epub 2007 May 7.