SMIFH2

• Supplier: Tocris Bioscience
• Catalog: 4375
• Prices: $109.00, $459.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 340316-62-3
• Chemical Name: 1-(3-Bromophenyl)-5-(2-furanylmethylene)dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione
• Formula: C15H9BrN2O3S
• Molecular Weight: 377.21
• Purity: >99 %
• Description: Inhibitor of formin homology 2 (FH2) domains. Prevents formin-mediated actin nucleation and barbed end elongation. Disrupts formin-dependent actin cytoskeletal structures in fission yeast and mammalian NIH 3T3 fibroblasts.

Product References

Identification and characterization of a small molecule inhibitor of - Identification and characterization of a small molecule inhibitor of

Rizvi SA, Neidt EM, Cui J, Feiger Z, Skau CT, Gardel ML, Kozmin SA, Kovar DR. Chem Biol. 2009 Nov 25;16(11):1158-68.

Contractility of the cell rear drives invasion of breast tumor cells in 3D - Contractility of the cell rear drives invasion of breast tumor cells in 3D

Poincloux R, Collin O, Lizarraga F, Romao M, Debray M, Piel M, Chavrier P. Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):1943-8.