SN 003

• Supplier: Tocris Bioscience
• Catalog: 4401
• Prices: $195.00
• Sizes: 10 mg
• Function Type: Antagonist
• Cas Number: 197801-88-0
• Chemical Name: N-(4-Methoxy-2-methylphenyl)-1-[1-(methoxymethyl)propyl]-6-methyl-1H-1,2,3-triazolo[4,5-c]pyridin-4-amine
• Formula: C19H25N5O2
• Molecular Weight: 355.43
• Purity: >98 %
• Description: Reversible corticotropin releasing factor receptor 1 (CRF 1 ) antagonist (K i values are 3.4 and 7.9 nM at rat and human CRF 1 respectively) that displays >1000-fold selectivity over CRF 2 receptors. Suppresses CRF-induced ACTH release in vitro (IC 50 = 241 nM) and is brain penetrant.

Product References

Synthesis and in vivo evaluation of [11C]SN003 as a PET ligand for CRF1 - Synthesis and in vivo evaluation of [11C]SN003 as a PET ligand for CRF1

Kumar JS, Majo VJ, Sullivan GM, Prabhakaran J, Simpson NR, Van Heertum RL, Mann JJ, Parsey RV. Bioorg Med Chem. 2006 Jun 15;14(12):4029-34. Epub 2006 Mar 10.

PET Imaging of CRF1 with [11C]R121920 and [11C]DMP696: is the target of - PET Imaging of CRF1 with [11C]R121920 and [11C]DMP696: is the target of

Sullivan GM, Parsey RV, Kumar JS, Arango V, Kassir SA, Huang YY, Simpson NR, Van Heertum RL, Mann JJ. Nucl Med Biol. 2007 May;34(4):353-61. Epub 2007 Mar 30.