SN 38

• Supplier: Tocris Bioscience
• Catalog: 4907
• Prices: $109.00, $455.00
• Sizes: 10 mg, 50 mg
• Cas Number: 86639-52-3
• Chemical Name: (4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione
• Formula: C22H20N2O5
• Molecular Weight: 392.4
• Purity: >98 %
• Description: Active metabolite of CPT-11 (Cat. No. 2688) that inhibits DNA topoisomerase I (IC 50 values are 0.74 and 1.9 μ M in P388 and Ehrlich cells respectively). Inhibits DNA and RNA synthesis (IC 50 values are 0.077 and 1.3 μ M respectively) but does not affect protein synthesis. Displays potent antitumor activity against a range of human tumor cell lines (IC 50 values are 3.3, 13, 19 and 22 nM for HCT-116, BEL-7402, HL60 and HELA cells respectively).

Product References

Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, - Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11,

Kawato Y, Aonuma M, Hirota Y, Kuga H, Sato K. Cancer Res. 1991 Aug 15;51(16):4187-91.

Synthesis and antitumor activity of the hexacyclic camptothecin derivatives. - Synthesis and antitumor activity of the hexacyclic camptothecin derivatives.

Gao H, Zhang X, Chen Y, Shen H, Pang T, Sun J, Xu C, Ding J, Li C, Lu W. Bioorg Med Chem Lett. 2005 Jul 1;15(13):3233-6.

Novel SN-38-incorporating polymeric micelles, NK012, eradicate vascular - Novel SN-38-incorporating polymeric micelles, NK012, eradicate vascular

Koizumi F, Kitagawa M, Negishi T, Onda T, Matsumoto S, Hamaguchi T, Matsumura Y. Cancer Res. 2006 Oct 15;66(20):10048-56.