| Name | SN-6 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 2684 |
| Prices | $165.00, $685.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 415697-08-4 |
| Chemical Name | 2-[[4-[(4-Nitrophenyl)methoxy]phenyl]methyl]-4-thiazolidinecarboxylicacidethylester |
| Formula | C20H22N2O5S |
| Molecular Weight | 402.16 |
| Purity | >99 % |
| Description | Selective Na + /Ca 2+ -exchange (NCX) inhibitor; displays some selectivity for NCX1. IC 50 values are 2.9, 16 and 8.6 μ M for inhibition of intracellular Na+-dependent 45 Ca 2+ uptake by cells expressing NCX1, NCX2 and NCX3 respectively. Has some affinity for mACh receptors (IC 50 = 18 μ M) but minimal activity against NCKX2 and various receptors and ion channels (IC 50 > 30 μ M). Preferentially blocks Ca 2+ influx mode and is more selective for NCX isoforms than KB-R7943 (Cat. No. 1244). Anti-ischemic; potently protects against hypoxia-induced renal tubular cell damage (IC 50 = 0.63 μ M). |
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Iwamoto T, Inoue Y, Ito K, Sakaue T, Kita S, Katsuragi T. Mol Pharmacol. 2004 Jul;66(1):45-55.
Iwamoto T. J Pharmacol Sci. 2004 Sep;96(1):27-32. Epub 2004 Sep 10.