SNAP 5089

• Supplier: Tocris Bioscience
• Catalog: 0598
• Prices: $139.00, $585.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 157066-77-8
• Chemical Name: 5-[[[3-(4,4-Diphenyl-1-piperidinyl)propyl]amino]carbonyl]-1,4-dihydro-2,6-dimethyl-4-(4-nitrophenyl)-3-pyridinecarboxylicacidmethylesterhydrochloride
• Formula: C36H40N4O5.HCl
• Molecular Weight: 645.19
• Purity: >98 %
• Description: Subtype-selective α 1A -adrenoceptor antagonist that displays > 600-fold selectivity over other adrenoceptors (K i values are 0.35, 220, 370, 540, 800 and 1200 nM for α 1A , α 1B , α 2C , α 1D , α 2B and α 2A subtypes respectively and 540 nM for L-type Ca 2+ channels). Inhibits noradrenalin-induced contractions in rabbit vascular and lower urinary tissues.

Product References

Discovery of alpha 1a-adrenergic receptor antagonists based on the L-type Ca2+ - Discovery of alpha 1a-adrenergic receptor antagonists based on the L-type Ca2+

Wetzel JM, Miao SW, Forray C, Borden LA, Branchek TA, Gluchowski C. J Med Chem. 1995 May 12;38(10):1579-81.

Pharmacological characterization of the uroselective alpha-1 antagonist Rec - Pharmacological characterization of the uroselective alpha-1 antagonist Rec

Leonardi A, Hieble JP, Guarneri L, Naselsky DP, Poggesi E, Sironi G, Sulpizio AC, Testa R. J Pharmacol Exp Ther. 1997 Jun;281(3):1272-83.

Alpha1L-adrenoceptor mediation of smooth muscle contraction in rabbit bladder - Alpha1L-adrenoceptor mediation of smooth muscle contraction in rabbit bladder

Kava MS, Blue DR Jr, Vimont RL, Clarke DE, Ford AP. Br J Pharmacol. 1998 Apr;123(7):1359-66.