( S )-SNAP 5114

• Supplier: Tocris Bioscience
• Catalog: 2398
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 157604-55-2
• Chemical Name: 1-[2-[tris(4-methoxyphenyl)methoxy]ethyl]-(S)-3-piperidinecarboxylicacid
• Formula: C30H35NO6
• Molecular Weight: 505.61
• Purity: >98 %
• Description: GABA transport inhibitor, showing selectivity for GAT-3 and GAT-2 (IC 50 values are 5, 21 and 388 μ M for hGAT-3, rGAT-2 and hGAT-1 respectively). Increases thalamic GABA levels and is an anticonvulsant following systemic administration in vivo .

Product References

Cloning of the human homologue of the GABA transporter GAT-3 and identification - Cloning of the human homologue of the GABA transporter GAT-3 and identification

Borden LA, Dhar TG, Smith KE, Branchek TA, Gluchowski C, Weinshank RL. Receptors Channels. 1994;2(3):207-13.

GABA transporter heterogeneity: pharmacology and cellular localization. - GABA transporter heterogeneity: pharmacology and cellular localization.

Borden LA. Neurochem Int. 1996 Oct;29(4):335-56.

GABA-level increasing and anticonvulsant effects of three different GABA uptake - GABA-level increasing and anticonvulsant effects of three different GABA uptake

Dalby NO. Neuropharmacology. 2000 Sep;39(12):2399-407.