SNAP 94847 hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 1561
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 487051-12-7
• Chemical Name: N-[3-[1-[[4-(3,4-Difluorophenoxy)phenyl]methyl]-4-piperidinyl]-4-methylphenyl]-2-methylpropanamidehydrochloride
• Formula: C29H32F2N2O2.HCl
• Molecular Weight: 515.03
• Purity: >98 %
• Description: Potent melanin-concentrating hormone receptor 1 (MCH 1 ) antagonist (K i = 2.2 nM, K D = 530 pM) that displays > 80-fold and > 500-fold selectivity over α 1A and D 2 receptors respectively. Increases neurogenesis in the dentate gyrus and decreases food-reinforced operant responding in vivo . Exhibits anxiolytic activity and is orally active.

Product References

Synthesis and SAR investigations for novel melanin-concentrating hormone 1 - Synthesis and SAR investigations for novel melanin-concentrating hormone 1

Chen CA, Jiang Y, Lu K, Daniewska I, Mazza CG, Negron L, Forray C, Parola T, Li B, Hegde LG, Wolinsky TD, Craig DA, Kong R, Wetzel JM, Andersen K, Marzabadi MR. J Med Chem. 2007 Aug 9;50(16):3883-90.

Efficacy of the MCHR1 antagonist - Efficacy of the MCHR1 antagonist

David DJ, Klemenhagen KC, Holick KA, Saxe MD, Mendez I, Santarelli L, Craig DA, Zhong H, Swanson CJ, Hegde LG, Ping XI, Dong D, Marzabadi MR, Gerald CP, Hen R. J Pharmacol Exp Ther. 2007 Apr;321(1):237-48. Epub 2007 Jan 19.

Effects of the MCH1 receptor antagonist SNAP 94847 on high-fat food-reinforced - Effects of the MCH1 receptor antagonist SNAP 94847 on high-fat food-reinforced

Nair SG, Adams-Deutsch T, Pickens CL, Smith DG, Shaham Y. Psychopharmacology (Berl). 2009 Jul;205(1):129-40. doi: