SNX 482

• Supplier: Tocris Bioscience
• Catalog: 4584
• Prices: $175.00
• Sizes: 10 µg
• Function Type: Blocker
• Cas Number: 203460-30-4
• Formula: C192H274N52O60S7
• Molecular Weight: 4495.01
• Description: Potent and selective, voltage-dependent R-type Ca V 2.3 calcium channel blocker (IC 50 = 30 nM). Antinociceptive; inhibits nociceptive C-fibre and A δ -fibre-evoked neuronal responses.

Product References

Selective peptide antagonist of the class E calcium channel from the venom of the - Selective peptide antagonist of the class E calcium channel from the venom of the

Newcomb R, Szoke B, Palma A, Wang G, Chen Xh, Hopkins W, Cong R, Miller J, Urge L, Tarczy-Hornoch K, Loo JA, Dooley DJ, Nadasdi L, Tsien RW, Lemos J, Miljanich G. Biochemistry. 1998 Nov 3;37(44):15353-62.

Interaction of SNX482 with domains III and IV inhibits activation gating of - Interaction of SNX482 with domains III and IV inhibits activation gating of

Bourinet E, Stotz SC, Spaetgens RL, Dayanithi G, Lemos J, Nargeot J, Zamponi GW. Biophys J. 2001 Jul;81(1):79-88.

The Cav2.3 calcium channel antagonist SNX-482 reduces dorsal horn neuronal - The Cav2.3 calcium channel antagonist SNX-482 reduces dorsal horn neuronal

Matthews EA, Bee LA, Stephens GJ, Dickenson AH. Eur J Neurosci. 2007 Jun;25(12):3561-9.