SP 100030

Name SP 100030
Supplier Tocris Bioscience
Catalog 0952
Prices $185.00, $755.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 154563-54-9
Chemical Name N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide
Formula C14H5ClF9N3O
Molecular Weight 437.65
Purity >99 %
Description Potent dual inhibitor of NF- κ B and AP-1 transcriptional activity (IC 50 = 50 nM). Blocks production of IL-2, IL-8 and TNF- α from Jurkat T cells. Inhibits cytokine production selectively in T cells; exhibits minimal inhibition of cytokine production in other cell types. Decreases arthritic severity in a mouse model of collagen-induced arthritis. Also ameliorates muscle wasting in a rat model of cancer cachexia.
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Product References

The effect of a T cell-specific NF-kappa B inhibitor on in vitro cytokine - The effect of a T cell-specific NF-kappa B inhibitor on in vitro cytokine

Gerlag DM, Ransone L, Tak PP, Han Z, Palanki M, Barbosa MS, Boyle D, Manning AM, Firestein GS. J Immunol. 2000 Aug 1;165(3):1652-8.

The AP-1/NF-kappaB double inhibitor SP100030 can revert muscle wasting during - The AP-1/NF-kappaB double inhibitor SP100030 can revert muscle wasting during

Moore-Carrasco R, Busquets S, Almendro V, Palanki M, Lopez-Soriano FJ, Argiles JM. Int J Oncol. 2007 May;30(5):1239-45.