Name | SP 600125 |
---|---|
Supplier | Tocris Bioscience |
Catalog | 5332 |
Prices | $109.00, $455.00 |
Sizes | 10 mg, 50 mg |
Function Type | Inhibitor |
Cas Number | 129-56-6 |
Chemical Name | Anthra[1-9-cd]pyrazol-6(2H)-one |
Formula | C14H8N2O |
Molecular Weight | 220.23 |
Purity | >98 % |
Description | Selective JNK inhibitor. Competitively and reversibly inhibits JNK1, 2 and 3 (IC 50 = 40 - 90 nM) with negligible activity at ERK2, p38 β and a range of enzymes. Active in vivo . Exhibits reduced selectivity over other protein kinases under certain conditions. Protects renal tubular epithelial cells against ischemia/reperfusion-induced apoptosis. Prevents BMP9-induced osteogenic differentiation of MSCs. Essential component of medium for maintaining stem cells in naive pluripotent state. Available as part of the MAPK Inhibitor Tocriset™ . |
Supplier Page | Shop |
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