SP 600125

Name SP 600125
Supplier Tocris Bioscience
Catalog 5332
Prices $109.00, $455.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 129-56-6
Chemical Name Anthra[1-9-cd]pyrazol-6(2H)-one
Formula C14H8N2O
Molecular Weight 220.23
Purity >98 %
Description Selective JNK inhibitor. Competitively and reversibly inhibits JNK1, 2 and 3 (IC 50 = 40 - 90 nM) with negligible activity at ERK2, p38 β and a range of enzymes. Active in vivo . Exhibits reduced selectivity over other protein kinases under certain conditions. Protects renal tubular epithelial cells against ischemia/reperfusion-induced apoptosis. Prevents BMP9-induced osteogenic differentiation of MSCs. Essential component of medium for maintaining stem cells in naive pluripotent state. Available as part of the MAPK Inhibitor Tocriset™ .
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