Spadin

• Supplier: Tocris Bioscience
• Catalog: 1496
• Prices: $149.00
• Sizes: 1 mg
• Function Type: Blocker
• Cas Number: 1270083-24-3
• Formula: C96H142N26O22
• Molecular Weight: 2012.34
• Description: Potent TREK-1 channel blocker (IC 50 = 71 nM). Enhances dorsal raphe nucleus 5-HT neurotransmission in mice. Induces hippocampal CREB activation and neurogenesis in adult mice. Exhibits antidepressant effects in mouse models of depression. Brain penetrant.

Product References

Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new - Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new

Mazella J, Petrault O, Lucas G, Deval E, Beraud-Dufour S, Gandin C, El-Yacoubi M, Widmann C, Guyon A, Chevet E, Taouji S, Conductier G, Corinus A, Coppola T, Gobbi G, Nahon JL, Heurteaux C, Borsotto M. PLoS Biol. 2010 Apr 13;8(4):e1000355.

Targeting two-pore domain K(+) channels TREK-1 and TASK-3 for the treatment of - Targeting two-pore domain K(+) channels TREK-1 and TASK-3 for the treatment of

Borsotto M, Veyssiere J, Moha Ou Maati H, Devader C, Mazella J, Heurteaux C. Br J Pharmacol. 2015 Feb;172(3):771-84.