Spautin 1

• Supplier: Tocris Bioscience
• Catalog: 1784
• Prices: $129.00, $535.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1262888-28-7
• Chemical Name: 6-Fluoro-N-[(4-Fluorophenyl)methyl]-4-quinazolinamine
• Formula: C15H11F2N3
• Molecular Weight: 271.26
• Purity: >98 %
• Description: Inhibitor of autophagy; inhibits USP10 and USP13 activity (IC 50 values are 0.6 and 0.7 μ M respectively) and promotes degradation of Vps34 (class III PI 3-kinase) complexes. Selectively promotes apoptosis of cancer cells under starvation conditions. Prevents the PDGF-induced conversion from the contractile to synthetic phenotype in vascular smooth muscle cells.

Product References

Beclin1 controls the levels of p53 by regulating the deubiquitination activity of - Beclin1 controls the levels of p53 by regulating the deubiquitination activity of

Liu J, Xia H, Kim M, Xu L, Li Y, Zhang L, Cai Y, Norberg HV, Zhang T, Furuya T, Jin M, Zhu Z, Wang H, Yu J, Li Y, Hao Y, Choi A, Ke H, Ma D, Yuan J. Cell. 2011 Sep 30;147(1):223-34.

PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and - PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and

Salabei JK, Cummins TD, Singh M, Jones SP, Bhatnagar A, Hill BG. Biochem J. 2013 May 1;451(3):375-88.