Spermine tetrahydrochloride

• Supplier: Tocris Bioscience
• Catalog: 0959
• Prices: $75.00
• Sizes: 100 mg
• Function Type: Modulator
• Cas Number: 306-67-2
• Chemical Name: N,N'-Bis(3-aminopropyl)-1,4-butanediaminetetrahydrochloride
• Formula: C10H26N4.4HCl
• Molecular Weight: 348.19
• Description: Polyamine which produces a variety of modulatory effects on the NMDA receptor channel, acting through a specific site on the complex which can cause both agonist and antagonist effects.

Product References

Multiple effects of spermine on N-methyl-D-aspartic acid receptor responses of - Multiple effects of spermine on N-methyl-D-aspartic acid receptor responses of

Benveniste M, Mayer ML. J Physiol. 1993 May;464:131-63.

Polyamines modulate the neurotoxic effects of NMDA in vivo. - Polyamines modulate the neurotoxic effects of NMDA in vivo.

Munir M, Subramaniam S, McGonigle P. Brain Res. 1993 Jul 9;616(1-2):163-70.

Modulation of channel function by polyamines. - Modulation of channel function by polyamines.

Johnson TD. Trends Pharmacol Sci. 1996 Jan;17(1):22-7.

Investigation of the actions and antagonist activity of some polyamine analogues - Investigation of the actions and antagonist activity of some polyamine analogues

Doyle KM, Shaw GG. Br J Pharmacol. 1998 May;124(2):386-90.