Sphingosine-1-phosphate

• Supplier: Tocris Bioscience
• Catalog: 0633
• Prices: $175.00
• Sizes: 1 mg
• Cas Number: 26993-30-6
• Chemical Name: (E)-D-erythro-2-amino-1-(dihydrogenphosphate)-4-octadecene-1,3-diol
• Formula: C18H38NO5P
• Molecular Weight: 379.48
• Purity: >98 %
• Description: Endogenous second messenger involved in the control of cell proliferation and motility, and Ca 2+ mobilization. Acts as an agonist at sphingosine-1-phosphate receptors (S1P 1-5 ) and as an activator of GPR3, GPR6 and GPR12. Effectors regulated include p38 MAP kinase, PLC, adenylyl cyclase, myosin light chain phosphatase and focal adhesion kinase.

Product References

Activation of a high affinity Gi protein-coupled plasma membrane receptor by - Activation of a high affinity Gi protein-coupled plasma membrane receptor by

van Koppen C, Meyer zu Heringdorf M, Laser KT, Zhang C, Jakobs KH, Bunemann M, Pott L. J Biol Chem. 1996 Jan 26;271(4):2082-7.

Sphingosine 1-phosphate signalling via the endothelial differentiation gene - Sphingosine 1-phosphate signalling via the endothelial differentiation gene

Pyne S, Pyne N. Pharmacol Ther. 2000 Nov;88(2):115-31.

Sphingosine 1-phosphate dynamically regulates myosin light chain phosphatase - Sphingosine 1-phosphate dynamically regulates myosin light chain phosphatase

Essler M, Retzer M, Ilchmann H, Linder S, Weber PC. Cell Signal. 2002 Jul;14(7):607-13.

Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of - Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of

Uhlenbrock K, Gassenhuber H, Kostenis E. Cell Signal. 2002 Nov;14(11):941-53.