Spironolactone

• Supplier: Tocris Bioscience
• Catalog: 0995
• Prices: $75.00
• Sizes: 50 mg
• Function Type: Antagonist
• Cas Number: 52-01-7
• Chemical Name: (7α,17α)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylicacidγ-lactone
• Formula: C24H32O4S
• Molecular Weight: 416.57
• Purity: >98 %
• Description: Competitive mineralocorticoid (aldosterone) receptor antagonist that exhibits antihypertensive activity in vivo . Also displays antiandrogen activity and inhibits steroid hormone biosynthesis.

Product References

Mineralocorticoid receptor antagonists: the evolution of utility and - Mineralocorticoid receptor antagonists: the evolution of utility and

Delyani JA. Kidney Int. 2000 Apr;57(4):1408-11.

A comparison of the aldosterone-blocking agents eplerenone and spironolactone. - A comparison of the aldosterone-blocking agents eplerenone and spironolactone.

Struthers A, Krum H, Williams GH. Clin Cardiol. 2008 Apr;31(4):153-8.

Contrasting effects of eplerenone and spironolactone on adrenal cell - Contrasting effects of eplerenone and spironolactone on adrenal cell

Ye P, Yamashita T, Pollock DM, Sasano H, Rainey WE. Horm Metab Res. 2009 Jan;41(1):35-9.