SPP 86

Name SPP 86
Supplier Tocris Bioscience
Catalog 1542
Prices $195.00, $805.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 1357349-91-7
Chemical Name 1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Formula C16H15N5
Molecular Weight 277.32
Purity >98 %
Description Potent RET inhibitor (IC 50 = 8 nM). Also exhibits inhibitory activity at EphA1, FGFR1, Flt4, Lck and Yes. Inhibits proliferation of HCT 116 and TPC1 cells in vitro . Cell permeable.
Supplier Page Shop

Product References

Design, synthesis and characterization of a highly effective inhibitor for - Design, synthesis and characterization of a highly effective inhibitor for

Klein M, Morillas M, Vendrell A, Brive L, Gebbia M, Wallace IM, Giaever G, Nislow C, Posas F, Grotli M. PLoS One. 2011;6(6):e20789.

Preparation of 3-substituted-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amines as - Preparation of 3-substituted-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amines as

Diner P, Alao JP, Soderlund J, Sunnerhagen P, Grotli M. J Med Chem. 2012 May 24;55(10):4872-6.