SR 0987

• Supplier: Tocris Bioscience
• Catalog: 1435
• Prices: $155.00, $655.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 303126-97-8
• Chemical Name: 2-Chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzamide
• Formula: C16H10ClF6NO2
• Molecular Weight: 397.7
• Purity: >98 %
• Description: T cell-specific ROR γ (ROR γ t) agonist (EC 50 = 800 nM in a gene reporter assay). Induces IL-17 expression and decreases PD-1 expression in T cells in vitro .

Product References

Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand. - Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand.

Solt LA, Kumar N, Nuhant P, Wang Y, Lauer JL, Liu J, Istrate MA, Kamenecka TM, Roush WR, Vidovic D, Schurer SC, Xu J, Wagoner G, Drew PD, Griffin PR, Burris TP. Nature. 2011 Apr 28;472(7344):491-4.

Regulation of expression of citrate synthase by the retinoic acid - Regulation of expression of citrate synthase by the retinoic acid

Crumbley C, Wang Y, Banerjee S, Burris TP. PLoS One. 2012;7(4):e33804.

Inflammatory T helper 17 cells promote depression-like behavior in mice. - Inflammatory T helper 17 cells promote depression-like behavior in mice.

Beurel E, Harrington LE, Jope RS. Biol Psychiatry. 2013 Apr 1;73(7):622-30.