SR 1078

• Supplier: Tocris Bioscience
• Catalog: 4868
• Prices: $149.00, $629.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 1246525-60-9
• Chemical Name: N-[4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4-(trifluoromethyl)benzamide
• Formula: C17H10F9NO2
• Molecular Weight: 431.25
• Purity: >98 %
• Description: Agonist of retinoic acid receptor-related orphan receptors (ROR) ROR α / γ . Increases transcription of ROR α target genes; thought to increase p53 stability.

Product References

Identification of SR1078, a synthetic agonist for the orphan nuclear receptors - Identification of SR1078, a synthetic agonist for the orphan nuclear receptors

Wang Y, Kumar N, Nuhant P, Cameron MD, Istrate MA, Roush WR, Griffin PR, Burris TP. ACS Chem Biol. 2010 Nov 19;5(11):1029-34.

Regulation of p53 stability and apoptosis by a ROR agonist. - Regulation of p53 stability and apoptosis by a ROR agonist.

Wang Y, Solt LA, Kojetin DJ, Burris TP. PLoS One. 2012;7(4):e34921.