SR 11302

• Supplier: Tocris Bioscience
• Catalog: 3411
• Prices: $199.00
• Sizes: 10 mg
• Function Type: Activator
• Cas Number: 160162-42-5
• Chemical Name: (E,E,Z,E)-3-Methyl-7-(4-methylphenyl)-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoicacid
• Formula: C26H32O2
• Molecular Weight: 376.54
• Purity: >98 %
• Description: Inhibitor of activator protein-1 (AP-1) transcription factor activity that displays antitumor effects in vivo . Does not activate transcription from the retinoic acid response element (RARE) and displays no activity at retinoic acid receptors (EC 50 > 1 μ M for RAR α , RAR β , RAR γ and RXR α ).

Product References

A new class of retinoids with selective inhibition of AP-1 inhibits - A new class of retinoids with selective inhibition of AP-1 inhibits

Fanjul A, Dawson MI, Hobbs PD, Jong L, Cameron JF, Harlev E, Graupner G, Lu XP, Pfahl M. Nature. 1994 Nov 3;372(6501):107-11.

Effects of novel RAR- and RXR-selective retinoids on myeloid leukemic - Effects of novel RAR- and RXR-selective retinoids on myeloid leukemic

Shiohara M, Dawson MI, Hobbs PD, Sawai N, Higuchi T, Koike K, Komiyama A, Koeffler HP. Blood. 1999 Mar 15;93(6):2057-66.